There is no sinning against God, what does God care about sin!
But there is sinning against the Holy Ghost, since the Holy Ghost is with us
in the flesh, is part of our consciousness.
The Holy Ghost is the deepest part of our own consciousness
wherein we know ourselves for what we are
and know our dependence on the creative beyond.
So if we go counter to our own deepest consciousness
naturally we destroy the most essential self in us,
and once done, there is no remedy, no salvation for this,
nonentity is our portion.